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Eastern Medicine Discovers The Secret To Achieving A Lean Body?

Traditional Eastern Medicine has included black pepper and its associated extracts for many years to treat a number of health ailments and for potential weight loss.

Piperine, which is the pungent component of black pepper, has been shown to possess anti-cancer properties, improve cognitive function, and act as an anti-depressant.

It has also been shown to increase the bioavailability of certain compounds, which could alter its effectiveness.

Eastern medicine has incorporated piperine to treat symptoms associated with gastro-intestinal stress, pain, inflammation, and many other diseases.

Now, according to a new study published in the Journal Agricultural and Food Chemistry, it could show that piperine is effective at slowing new fat cell formation.

Let me explain…

Piperine and Adipogenesis

When you eat a high-fat diet, your fat cells take on the excess calories and store it until the cells are full.

The fat cells then send out a signal to immature fat cells, called pre-adipocytes, which will then start to grow and mature into full-fledged fat cells.

This process is termed adipogenesis, where an immature fat cell becomes a full-fledged fat cell.

Some clinical studies show that piperine may be able to inhibit adipogenesis.

The authors of this study wanted to investigate the effect of black pepper extract and piperine in 3T3-L4 pre-adipocytes as well as its underlying mechanism for halting adipogenesis.

They showed that without affecting cytotoxicity, piperine strongly inhibited the adipocyte differentiation that could occur in 3T3-L1 adipocyte cells

Adipocyte differentiation simply means when an unspecialized fat cell takes on specific features of an adipocyte (fat cell).

They showed that piperine decreased the activity of transcriptional factors PPARy, SREBP-1c, and C/EBPB which are associated with fat cell differentiation.

They also noted that mRNA levels of PPARy target genes were down-regulated when piperine was introduced.

Simply put, piperine may be able to stop undeveloped fat cells from developing into full functioning fat cells

The researchers showed that piperine significantly repressed the rosiglitazone-induced PPARy transcriptional activity and that piperine was able to disrupt the rosiglitazone-dependent interaction between PPARy and co-activator CBP. 

On an interesting note, their research supports the role of piperine and lipid metabolism.

From their work, they concluded that piperine could slow fat cell differentiation by down-regulating PPARy activity and suppressing PPARy expression.

When piperine was introduced, specific genes (PPARy, SREBP-1c, and C/EBPB) which are responsible for the growth and development of new fat cells, could slow down and stop functioning correctly. 

This halts the process of those same non-developed fat cells (pre-adipocytes) from becoming full-fledged fat cells (adipocytes) and taking on excess calories to store for later use.

Although the research is new and exciting, it still needs more research to validate their findings.  

The researchers  however, stress that this could be a new treatment option for overweight and obesity, because it could slow the process of making immature fat cells into new fat cells by blocking specific key components that contribute to the new fat cell production.

Black Pepper and Weight Loss

Black pepper and black pepper extract has been used for a number of years in Eastern medicine to treat many different health ailments.

It has been used as a way to treat gastro-intestinal stress, pain, inflammation; and now it may stop fat cell differentiation and adipogenesis.

According to this study, piperine, which is an analog of black pepper, could down-regulate key genes responsible for the maturing of pre-adipocytes into new, mature fat cells (adipogenesis).

Piperine has also been shown to inhibit cancer cell formation, improve cognitive function, could act as an anti-depressant, and now could be a new treatment option for treating overweight and obese individuals.

 

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References:

Park, UH.  Jeong, HS.  Jo, EY.  Park, T.  Yoon, SK.  Kim, EJ.  Jeong, JC.  Um, SJ.  Piperine, a Component of Black Pepper, Inhibits Adipogenesis by Antagonizing PPARy Activity in 3T3-L1 Cells.  Journal of Agricultural and Food Chemistry.  2012.  Vol. 60(15):pp.3853-3860.  doi: 10.1021/jf204514a.